ESR 5 vision / project
Role of the G-protein-coupled receptor Gpr126 signalling in the development of the blood-brain barrier.
Study the role of GPCR signaling through the orphan receptor Gpr126 in brain angiogenesis and BBB formation Define the molecular mechanisms of Gpr126 and its downstream partners in the formation of the BBB Identify agonists/ antagonists of Gpr126, which might have therapeutic impact in the regulation of the BBB under pathological conditions.
Definition of a new signalling pathway in brain endothelial cells, to identify novel targets for the recovery of the BBB properties under pathological conditions. Identification of Gpr126 antagonists to transiently increase BBB permeability and allow the passage of therapeutic agents. Studies on the role of inward and outward transporters.
Fondazione Istituto FIRC di Oncologia Molecolare, Biosciences, Milano, Italy
Early Stage Researcher