In vitro models of the blood-brain and blood-CSF barriers using an integrated microfluidic device
© Manu Friederich / Universität Bern

ESR 2 vision / project

Ana Raquel Santa Maria - Biological Research Centre

ESR 2

In vitro models of the blood-brain and blood-CSF barriers using an integrated microfluidic device

Objectives

Study microfluidic co-culture models of the BBB and BCSFB using a custom integrated microelectronic device with a focus on human models. Bioengineering of 3D co-culture models of the BBB using Reversible Addition Fragmentation Chain Transfer (RAFT) technology.

Expected Results

Establishment of novel human BBB and BCSFB models and insight into the effect of cell interactions and flow on BBB and BCSFB barrier properties.

Hosting institution

Biological Research Centre, HAS, Biological Barriers research group, Hungary

Supervisor

Maria Deli

Early Stage Researcher

Ana Raquel Santa Maria