ESR 12 vision / project
Molecular control of the human brain barriers in health and neuroinflammation
Investigation of downstream targets of microRNAs and transcription factors known to control human blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) function using deep sequencing and functional assays for the BBB and BCSFB function. Relevance of identified pathways and altered expression thereof will be validated. Expression of identified targets will be verified in human pathological conditions, predominantly multiple sclerosis (MS).
Identification of molecular pathways involved in BBB and BCSFB dysfunction allowing to define therapeutic targets for restoring brain barriers dysfunction in neuroinflammatory disorders.
Stichting VU University Amsterdam & VU Medical Center Amsterdam, Molecular Cell Biology and Immunology, Netherlands
Elga de Vries
Early Stage Researcher