Molecular control of the human brain barriers in health and neuroinflammation
© Manu Friederich / Universität Bern

ESR 12 vision / project

Sabela Rodriguez - Stichting VU University Amsterdam & VU Medical Center Amsterdam

ESR 12

Molecular control of the human brain barriers in health and neuroinflammation

Objectives

Investigation of downstream targets of microRNAs and transcription factors known to control human blood-brain barrier (BBB) and blood-CSF barrier (BCSFB) function using deep sequencing and functional assays for the BBB and BCSFB function. Relevance of identified pathways and altered expression thereof will be validated. Expression of identified targets will be verified in human pathological conditions, predominantly multiple sclerosis (MS).

Expected Results

Identification of molecular pathways involved in BBB and BCSFB dysfunction allowing to define therapeutic targets for restoring brain barriers dysfunction in neuroinflammatory disorders.

Hosting institution

Stichting VU University Amsterdam & VU Medical Center Amsterdam, Molecular Cell Biology and Immunology, Netherlands

Main Supervisor

Elga de Vries

Early Stage Researcher

Sabela Rodriguez