ESR 3 vision / project
Comparison of mouse and zebrafish cerebral endothelial cell transcriptomes and functional investigation of conserved pathways governing brain angiogenesis and BBB formation
Employing novel in vivo BBB labelling techniques to profile (RNAseq) microvascular endothelial cell gene expression during development, in adults and in previously generated mutant zebrafish embryos with defective BBB properties. Cross-species bioinformatic comparison of the zebrafish BBB transcriptome to analogous expression datasets from mouse embryos will be performed to identify evolutionary conserved pathways and regulatory networks. Analysis of candidate genes and pathways in zebrafish via loss-of-function approaches.
Uncovering molecular pathways that instruct BBB formation and maintenance in vertebrates.
Universite Libre de Bruxelles, Laboratory of Neurovascular Signaling, Belgium
Early Stage Researcher
Raoul Freitas Vale Germano