Exploring CD4+ T cells as carriers to mediate transport of drugs across the blood-brain barrier
© Manu Friederich / Universität Bern

ESR 10 vision / project

Markus Schuster - UÉcole Polytechnique Fédérale de Lausanne

ESR 10

Exploring CD4+ T cells as carriers to mediate transport of drugs across the blood-brain barrier

Objectives

Development of cell surface engineered CD4+ cells will allow the immobilization of drugs or drug carriers on the surface of CD4+ T cells. Study if surface-engineered CD4+ T cells are able to cross the BBB under flow in vitro and in vivo and if they can release drugs at the abluminal side

Expected Results

Protocols for the preparation of surface engineered T cells able to cross the BBB.

Hosting institution

École Polytechnique Fédérale de Lausanne, Polymers Laboratory, Lausanne, Switzerland

Main Supervisor

Harm-Anton Klok

Early Stage Researcher

Markus Schuster