Blood-brain barrier derived non-conding RNAs as functional biomarkers for the aging BBB versus the BBB in Alzheimer’s Disease

ESR 7 vision / project

Ricardo Figueiredo - GenXPro GmbH

ESR 7

Blood-brain barrier derived non-conding RNAs as functional biomarkers for the aging BBB versus the BBB in Alzheimer’s Disease

Objectives

Based on the knowledge that altered expression of noncoding RNAs (ncRNAs) are a hallmark of many neuropsychiatric disorders including Alzheimer's disease (AD), we hypothesize that ncRNA signatures in blood reflect AD-related changes in the ncRNA profile of the BBB and may therefore be used as functional biomarkers for AD. Making use of ageing mice and transgenic mouse models of AD we will address the following tasks: Create the technical prerequisites for NGS analyses of the minute amounts of ncRNAs present in the blood of mice. Determine the most informative blood compartment (whole blood, plasma) for biomarker generation. Determine whether ncRNA profiles from BBB ECs of AD-affected and healthy aged mice correlate with ncRNA profiles from blood of these mice.

Expected Results

Define if blood ncRNA profiles reflect dysfunction of the BBB in AD.

Hosting institution

GenXPro GmbH, Frankfurt, Germany

Main Supervisor

Peter Winter

Early Stage Researcher

Ricardo Figueiredo