In vitro models of the BBB and applications in pharmacological and toxicological screenings
© Manu Friederich / Universität Bern

ESR 1 vision / project

Marjolein Heymans - Universite D’artois

ESR 1

In vitro models of the BBB and applications in pharmacological and toxicological screenings

Objectives

Comparing the free brain/free plasma ratios of a set of marketed drugs, in established and to be developed human and rat in vitro BBB models, to the in vivo data available in the same species.
Understanding potential species differences by analysing the expression profile of transporters and key metabolizing enzymes in freshly isolated CNS capillaries and the respective in vitro BBB models of rat and human.
Using the CD34+ derived human in vitro BBB model to study the effects on BBB function by repeated drug exposure at the BBB.

Expected Results

Definition of the usefulness of specific in vitro BBB models to predict the CNS drug delivery in humans in vivo. Understanding the effects of chronic drug exposure to BBB function.

Hosting institution

UNIVERSITE D’ARTOIS, BBB Lab, Arras, France

Supervisor

Maxime Culot

Early Stage Researcher

Marjolein Heymans