Role of the G-protein-coupled receptor Gpr126 signalling in the development of the blood-brain barrier
© Manu Friederich / Universität Bern

ESR 5 vision / project

Nikolaos Kakogiannos - Fondazione Istituto FIRC di Oncologia Molecolare

ESR 5

Role of the G-protein-coupled receptor Gpr126 signalling in the development of the blood-brain barrier.

Objectives

Study the role of GPCR signaling through the orphan receptor Gpr126 in brain angiogenesis and BBB formation Define the molecular mechanisms of Gpr126 and its downstream partners in the formation of the BBB Identify agonists/ antagonists of Gpr126, which might have therapeutic impact in the regulation of the BBB under pathological conditions.

Expected Results

Definition of a new signalling pathway in brain endothelial cells, to identify novel targets for the recovery of the BBB properties under pathological conditions. Identification of Gpr126 antagonists to transiently increase BBB permeability and allow the passage of therapeutic agents. Studies on the role of inward and outward transporters.

Hosting institution

Fondazione Istituto FIRC di Oncologia Molecolare, Biosciences, Milano, Italy

Supervisor

Elisabetta Dejana

Early Stage Researcher

Nikolaos Kakogiannos