Role of different receptors in promoting pathogen and leukocyte migration across the BCSFB in meningitis
© Manu Friederich / Universität Bern

ESR 11 vision / project

Marie Wiatr - University Heidelberg

ESR 11

Role of different receptors in promoting pathogen and leukocyte migration across the BCSFB in meningitis

Objectives

  • Exploring the epithelial cell surface components mediating adhesion, invasion or transmigration of meningitis causing pathogens to/into/across the human BCSFB (HIBCPP model) in vitro
  • Analyzing the host cell response induced by meningitis causing pathogens promoting leukocyte migration across HIBCPP in vitro
  • Exploring the therapeutic potential of blocking identified targets for pathogen and leukocyte entry into the CNS across the BCSFB in vitro and possibly using mouse models in vivo

Expected Results

Understanding of the role of cell surface components and host cell response in directing pathogen and/or leukocyte migration across the human BCSFB during CNS infections

Hosting institution

University Heidelberg, University Children`s Hospital Mannheim, Germany

Main Supervisor

Tobias Tenenbaum and Horst Schroten

Early Stage Researcher

Marie Wiatr